Hydrochloric Acid → HCID 71532717, compound

HRID 1505772Notes

Reaction equation

HRID 1505772 reaction equation
[Cl:1][C:2]1[C:3]([CH3:36])=[C:4]([NH:8][C:9]([C:11]2[C:19]3[N:18]=[C:17]([CH2:20][O:21][CH3:22])[NH:16][C:15]=3[CH:14]=[C:13]([NH:23][C:24]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]([F:35])([F:34])[F:33])=[O:25])[CH:12]=2)=[O:10])[CH:5]=[CH:6][CH:7]=1.Cl>CCO>[ClH:1].[Cl:1][C:2]1[C:3]([CH3:36])=[C:4]([NH:8][C:9]([C:11]2[C:19]3[N:18]=[C:17]([CH2:20][O:21][CH3:22])[NH:16][C:15]=3[CH:14]=[C:13]([NH:23][C:24]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]([F:33])([F:34])[F:35])=[O:25])[CH:12]=2)=[O:10])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 712674451422203-86-8

Product 1

HCID 71532717HCID 71532717, compoundYield 189.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-(3-chloro-2-methylphenyl)-2-(methoxymethyl)-6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxamide (165 mg) obtained in Step 7 was suspended in EtOH (3 mL). To the suspension was added 1M hydrochloric acid (0.32 mL), it was stirred to obtain a homogeneous solution, and the solvent was removed under reduced pressure. The residue was triturated in ethyl acetate, collected by filtration, and dried to obtain the titled compound (167 mg) as colorless powder.

Workup

  1. customto obtain a homogeneous solution
  2. customthe solvent was removed under reduced pressure
  3. customThe residue was triturated in ethyl acetate
  4. filtrationcollected by filtration
  5. customdried

Sources & evidence

ORD record
ord-6f88d434270842f4964b1e11fea51d1e
Source dataset
uspto-grants-2015_12
Patent number
US09216968B2

Reaction notes

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