HCID 90229450, compound → HCID 90229556, compound

HRID 1505794Notes

Reaction equation

HRID 1505794 reaction equation
[Cl:1][C:2]1[NH:6][C:5]2[CH:7]=[C:8]([N+:15]([O-])=O)[CH:9]=[C:10]([C:11]([O:13][CH3:14])=[O:12])[C:4]=2[N:3]=1>CO.[Pt]>[NH2:15][C:8]1[CH:9]=[C:10]([C:11]([O:13][CH3:14])=[O:12])[C:4]2[N:3]=[C:2]([Cl:1])[NH:6][C:5]=2[CH:7]=1

Participants

4

Reactant 1

HCID 90229450HCID 90229450, compound

Product 1

HCID 90229556HCID 90229556, compoundYield 101.6%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

To a solution of methyl 2-chloro-6-nitro-1H-benzimidazole-4-carboxylate (0.87 g) in MeOH (100 mL), was added 1% platinum+0.1% copper-activated carbon (Degussa type CF105 R/W) (0.19 g), and the mixture was stirred under hydrogen atmosphere (0.2 MPa) for 4 hours. The reaction mixture was filtered off through celite and washed with MeOH. The mother liquid was concentrated to obtain the titled compound (0.78 g) as yellow powder.

Workup

  1. filtrationThe reaction mixture was filtered off through celite
  2. washwashed with MeOH
  3. concentrationThe mother liquid was concentrated

Sources & evidence

ORD record
ord-e07f4b5b2a704d9ab7bc20e03b2816d7
Source dataset
uspto-grants-2015_12
Patent number
US09216968B2

Reaction notes

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