Methanesulfonic Acid → HCID 90313396, compound

HRID 1505813Notes

Reaction equation

HRID 1505813 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([C:12]2[C:20]3[N:19]=[C:18]([N:21]([CH3:23])[CH3:22])[NH:17][C:16]=3[CH:15]=[C:14]([NH:24][C:25]([C:27]3[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:28]=3[Cl:34])=[O:26])[CH:13]=2)=[O:11])[CH:5]=[CH:6][C:7]=1[CH3:8].[CH3:35][S:36]([OH:39])(=[O:38])=[O:37]>CO>[CH3:35][S:36]([OH:39])(=[O:38])=[O:37].[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([C:12]2[C:20]3[N:19]=[C:18]([N:21]([CH3:22])[CH3:23])[NH:17][C:16]=3[CH:15]=[C:14]([NH:24][C:25]([C:27]3[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:28]=3[Cl:34])=[O:26])[CH:13]=2)=[O:11])[CH:5]=[CH:6][C:7]=1[CH3:8]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 71267454HCID 71267454, compound

Product 1

HCID 90313396HCID 90313396, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of N-(3-chloro-4-methylphenyl)-6-{[(2,5-dichlorophenyl)carbonyl]amino}-2-(dimethylamino)-1H-benzimidazole-4-carboxamide (200 mg) (obtained in Example 207) in MeOH (2 ml), was added methanesulfonic acid (1 Eq). The mixture was stirred at room temperature for 30 minutes, and filtered off through glass filter to collect crystals, which were dried under reduced pressure to obtain the titled compound (180 mg) as white powder.

Workup

  1. filtrationfiltered off through glass
  2. filtrationfilter
  3. customto collect crystals, which
  4. customwere dried under reduced pressure

Sources & evidence

ORD record
ord-a0ed11e2dfb742d3b0c1fd20025a024e
Source dataset
uspto-grants-2015_12
Patent number
US09216968B2

Reaction notes

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