反应详情

A solution of (6-methoxy-4-iodo-pyridin-3-yl)-carbamic acid tert-butyl ester (18 g, 51 mmol) in DCM (50 mL) and TFA (50 mL) was stirred at ambient temperature for 1 h and then evaporated in vacuo. The resultant residue was treated with saturated aqueous sodium hydrogen carbonate solution (25 mL), diluted with water (100 mL) and extracted into ethyl acetate (2×100 mL). The organic layer was separated, dried over sodium sulfate, filtered and evaporated in vacuo to afford the title compound as a brown foam (10 g, 60%).

1. customevaporated in vacuo
2. additionThe resultant residue was treated with saturated aqueous sodium hydrogen carbonate solution (25 mL)
3. additiondiluted with water (100 mL)
4. extractionextracted into ethyl acetate (2×100 mL)
5. customThe organic layer was separated
6. dry with materialdried over sodium sulfate
7. filtrationfiltered
8. customevaporated in vacuo