Thiazole → HCID 67980702, compound

Participants

Reaction Conditions

Reaction Steps

15.46 g (0.10 mol) of 2-chloroacetophenone was weighed out and dissolved in 60 ml ethyl acetate. The clear solution was heated to 75° C. and 4.4 ml (0.0624 mmol) thiazole was added drop wise with stirring. The resulting clear solution was then stirred under reflux for 3.5 hours and then allowed to stand under a nitrogen atmosphere for one day; the resulting suspension was filtered off under suction and dried in a high vacuum. Yield: 1.94 g (13%).

Provenance & Evidence