Thiazole → HCID 67980702, compound

HRID 1506088Notes

Reaction equation

HRID 1506088 reaction equation
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].[S:11]1[CH:15]=[CH:14][N:13]=[CH:12]1>C(OCC)(=O)C>[Cl-:1].[CH2:2]([C:12]1[S:11][CH:15]=[CH:14][NH+:13]=1)[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 9256ThiazoleHCID 107572-Chloroacetophenone

Product 1

HCID 67980702HCID 67980702, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
75 °C

Procedure

15.46 g (0.10 mol) of 2-chloroacetophenone was weighed out and dissolved in 60 ml ethyl acetate. The clear solution was heated to 75° C. and 4.4 ml (0.0624 mmol) thiazole was added drop wise with stirring. The resulting clear solution was then stirred under reflux for 3.5 hours and then allowed to stand under a nitrogen atmosphere for one day; the resulting suspension was filtered off under suction and dried in a high vacuum. Yield: 1.94 g (13%).

Workup

  1. stirringThe resulting clear solution was then stirred
  2. temperatureunder reflux for 3.5 hours
  3. filtrationthe resulting suspension was filtered off under suction
  4. customdried in a high vacuum

Sources & evidence

ORD record
ord-a491239f8bea454ab5f6cd167453f246
Source dataset
uspto-grants-2015_12
Patent number
US09217222B2

Reaction notes

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