HCID 136227340, compound → HCID 136341305, compound

HRID 1506167Notes

Reaction equation

HRID 1506167 reaction equation
[C:1]1([CH:13]2[CH2:18][CH2:17][CH2:16][N:15](C(OCC3C=CC=CC=3)=O)[CH2:14]2)[N:2]=[N:3][N:4]2[C:9]=1[C:8]1[CH:10]=[CH:11][NH:12][C:7]=1[N:6]=[CH:5]2>C(O)C.[C].[Pd]>[NH:15]1[CH2:16][CH2:17][CH2:18][CH:13]([C:1]2[N:2]=[N:3][N:4]3[C:9]=2[C:8]2[CH:10]=[CH:11][NH:12][C:7]=2[N:6]=[CH:5]3)[CH2:14]1

Participants

4

Reactant 1

HCID 136227340HCID 136227340, compound

Product 1

HCID 136341305HCID 136341305, compoundYield 100.1%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

Benzyl 3-(7H-pyrrolo[3,2-e][1,2,3]triazolo[1,5-c]pyrimidin-1-yl)piperidine-1-carboxylate (25.0 mg, 0.0664 mmol) in ethanol was stirred with 5% palladium-carbon (10 mg) under a hydrogen atmosphere at 50° C. for 2.5 hours. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to give the title compound as a light brown solid (16.1 mg, yield quantitative).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-4c46ba158bb64394bc18a117615939a8
Source dataset
uspto-grants-2015_12
Patent number
US09216999B2

Reaction notes

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