HCID 136341325, compound → HCID 136341327, compound

HRID 1506185Notes

Reaction equation

HRID 1506185 reaction equation
[C:1]1([CH:13]2[CH2:18][CH2:17][C:16](=[CH:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:15][CH2:14]2)[N:2]=[N:3][N:4]2[C:9]=1[C:8]1[CH:10]=[CH:11][NH:12][C:7]=1[N:6]=[CH:5]2.C1(C2CCC(=CC#N)CC2)N=NN2C=1C1C=CNC=1N=C2>>[C:1]1([CH:13]2[CH2:14][CH2:15][CH:16]([CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:17][CH2:18]2)[N:2]=[N:3][N:4]2[C:9]=1[C:8]1[CH:10]=[CH:11][NH:12][C:7]=1[N:6]=[CH:5]2

Participants

3

Reactant 2

HCID 136341325HCID 136341325, compoundHCID 136341328HCID 136341328, compound

Product 1

HCID 136341327HCID 136341327, compoundYield 51%

Procedure

The reactions in Synthetic Examplea 435 were carried out in substantially the same manners except that ethyl 2-[4-(7H-pyrrolo[3,2-e][1,2,3]triazolo[1,5-c]pyrimidin-1-yl)cyclohexylidene]acetate obtained in Synthetic Examplea 436 was used instead of 2-[4-(7H-pyrrolo[3,2-e][1,2,3]triazolo[1,5-c]pyrimidin-1-yl)cyclohexylidene]acetonitrile to give the title compound as a colorless solid (cis/trans mixture; 29.0 mg, yield 51%).

Workup

  1. customobtained in Synthetic Examplea 436

Sources & evidence

ORD record
ord-cb7b43be3d7f46b7bb0905b81d6211b3
Source dataset
uspto-grants-2015_12
Patent number
US09216999B2

Reaction notes

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