Acetyl chloride → HCID 178496611, compound

HRID 1506250Notes

Reaction equation

HRID 1506250 reaction equation
[CH3:1][O:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9]C(=O)OC(C)(C)C)[CH2:5][CH2:4]1.C([Cl:20])(=O)C>C(O)C>[ClH:20].[CH3:1][O:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([NH2:9])[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 178496620HCID 178496620, compound

Product 1

HCID 178496611HCID 178496611, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

tert-Butyl (trans-4-methoxycyclohexyl)carbamate in ethanol (5 mL) was stirred with acetyl chloride (1.5 mL) for one day under cooling with ice, and the solvent was concentrated under reduced pressure to give the title compound (475 mg, yield 95%).

Workup

  1. temperatureunder cooling with ice
  2. concentrationthe solvent was concentrated under reduced pressure

Sources & evidence

ORD record
ord-6fa177b3cd6d47d3a0a132e1b3831867
Source dataset
uspto-grants-2015_12
Patent number
US09216999B2

Reaction notes

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