反应详情

温度

80 °C

In a reaction flask, 4-(tert-butyl)pyridine (13.5 g, 99.8 mmol) was dissolved in 70 ml of acetic acid (1.29 mmol), and 30 ml of hydrogen peroxide (H2O2) (30%, 0.30 mol) was then slowly added to obtain a mixture. The mixture was heated to 80° C. for reaction for 24 hours, and the temperature was then slowly reduced to 20° C. The reaction flask was vacuum pumped to remove solvents from the mixture, followed by addition of a sodium hydroxide aqueous solution to adjust the pH of the mixture to 8. Next, the mixture was washed several times with dichloromethane and with deionized water to collect an organic layer, and the organic layer was dehydrated using sodium sulfate (Na2SO4). The solvent was then removed from the organic layer, followed by vacuum drying, thereby obtaining light yellow solids (13 g, 87% yield), which was Compound L4-1 having a chemical structure represented by

1. customto obtain a mixture
2. customwas then slowly reduced to 20° C
3. customto remove solvents from the mixture
4. additionfollowed by addition of a sodium hydroxide aqueous solution
5. washNext, the mixture was washed several times with dichloromethane
6. customwith deionized water to collect an organic layer
7. customThe solvent was then removed from the organic layer
8. customdrying