反应详情

To a solution of 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylic acid (Intermediate I-3D, 300 mg, 1.167 mmol) in dichloromethane (4 mL) at 0° C. was added oxalyl chloride (0.204 mL, 2.333 mmol) and a few drops of N,N-dimethylformamide, and the mixture was stirred at the same temperature for 20 min. Next, the reaction mixture was stirred for 5 min at room temperature, and the solvent and excess oxalyl chloride were evaporated off. The residue was dissolved in anhydrous dichloromethane and evaporated to give an oily residue which became solid upon drying under vacuum. The solid material was dissolved in 5 mL of dichloromethane and 2-amino-6-methoxy-3,4-dihydronaphthalen-1(2H)-one hydrochloride (223 mg, 1.167 mmol, J. Heterocyclic Chem., 29:1245 (1992)), diisopropylethylamine (0.61 mL, 3.50 mmol), and 4-(dimethylamino)pyridine (7.13 mg, 0.058 mmol) were added. The reaction mixture was stirred at room temperature for 2 hrs. The reaction mixture was extracted with ethyl acetate, washed with 1N HCl, saturated sodium bicarbonate and brine. The ethyl acetate layer was dried over sodium sulfate and evaporated to give a dark green solid residue. The product was crystallized from ethyl acetate and hexane to give 317 mg of the desired N-(6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxamide. The mother liquor was purified by Combiflash (40 g silica gel) eluting with 2:8 ethyl acetate-hexane to give additional 119 mg of the product (87% yield). 1H NMR (400 MHz, CDCl3) δ ppm 8.05 (1H, d, J=8.80 Hz), 7.82 (1H, br. s.), 7.61 (2H, d, J=6.82 Hz), 7.47-7.58 (3H, m), 6.89 (1H, dd, J=8.80, 2.42 Hz), 6.75 (1H, d, J=2.20 Hz), 4.77 (1H, ddd, J=13.31, 4.84, 4.73 Hz), 3.90 (3H, s), 3.23-3.36 (1H, m), 3.02-3.10 (1H, m), 2.94-3.02 (1H, m), 1.96-2.10 (1H, m).

1. stirringNext, the reaction mixture was stirred for 5 min at room temperature
2. customthe solvent and excess oxalyl chloride were evaporated off
3. dissolutionThe residue was dissolved in anhydrous dichloromethane
4. customevaporated
5. customto give an oily residue which
6. customupon drying under vacuum
7. dissolutionThe solid material was dissolved in 5 mL of dichloromethane
8. stirringThe reaction mixture was stirred at room temperature for 2 hrs
9. extractionThe reaction mixture was extracted with ethyl acetate
10. washwashed with 1N HCl, saturated sodium bicarbonate and brine
11. dry with materialThe ethyl acetate layer was dried over sodium sulfate
12. customevaporated
13. customto give a dark green solid residue
14. customThe product was crystallized from ethyl acetate and hexane