3-(1-methyl-7-vinyl-4,5-dihydro-1H-benzo[g]indazol-3-yl)-5-phenyl-4-(trifluoromethyl)isoxazole → 1-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydro-1H-benzo[g]indazole-7-carbaldehyde

HRID 1506473Notes

Reaction equation

HRID 1506473 reaction equation
C(C1C=CC(C2[O:15]N=C3C4C(CCC=23)=CC(C=O)=CC=4)=CC=1C(F)(F)F)C(C)C.[CH3:30][N:31]1[C:39]2[C:38]3[CH:40]=[CH:41][C:42]([CH:44]=C)=[CH:43][C:37]=3[CH2:36][CH2:35][C:34]=2[C:33]([C:46]2[C:50]([C:51]([F:54])([F:53])[F:52])=[C:49]([C:55]3[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=3)[O:48][N:47]=2)=[N:32]1>>[CH3:30][N:31]1[C:39]2[C:38]3[CH:40]=[CH:41][C:42]([CH:44]=[O:15])=[CH:43][C:37]=3[CH2:36][CH2:35][C:34]=2[C:33]([C:46]2[C:50]([C:51]([F:53])([F:52])[F:54])=[C:49]([C:55]3[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=3)[O:48][N:47]=2)=[N:32]1

Participants

3

Reactant 2

HCID 671711773-(1-methyl-7-vinyl-4,5-dihydro-1H-benzo[g]indazol-3-yl)-5-phenyl-4-(trifluoromethyl)isoxazoleHCID 866698863-(4-Isobutyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

Product 1

HCID 866699191-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydro-1H-benzo[g]indazole-7-carbaldehyde

Procedure

This compound was prepared according to the general procedure described for Preparation 23D, employing 50 mgs of 3-(1-methyl-7-vinyl-4,5-dihydro-1H-benzo[g]indazol-3-yl)-5-phenyl-4-(trifluoromethyl)isoxazole (78B). Yield: 48 mgs (96%); LC/MS M+1=424.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-d22ca945b3204f62b2f48432ead516da
Source dataset
uspto-grants-2015_12
Patent number
US09216972B2

Reaction notes

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