3-(2-methyl-7-vinyl-4,5-dihydro-2H-benzo[g]indazol-3-yl)-5-phenyl-4-(trifluoromethyl)isoxazole → 2-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydro-2H-benzo[g]indazole-7-carbaldehyde

HRID 1506474Notes

Reaction equation

HRID 1506474 reaction equation
C(C1C=CC(C2ON=[C:13]3[C:16]4[C:21]([CH2:22][CH2:23][C:12]=23)=[CH:20][C:19]([CH:24]=[O:25])=[CH:18][CH:17]=4)=CC=1C(F)(F)F)C(C)C.[CH3:30][N:31]1[C:39]([C:40]2[C:44]([C:45]([F:48])([F:47])[F:46])=[C:43]([C:49]3[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=3)[O:42][N:41]=2)=C2C(C3C=CC(C=C)=CC=3CC2)=[N:32]1>>[CH3:30][N:31]1[C:39]([C:40]2[C:44]([C:45]([F:47])([F:46])[F:48])=[C:43]([C:49]3[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=3)[O:42][N:41]=2)=[C:12]2[C:13]([C:16]3[CH:17]=[CH:18][C:19]([CH:24]=[O:25])=[CH:20][C:21]=3[CH2:22][CH2:23]2)=[N:32]1

Participants

3

Reactant 2

HCID 671689913-(2-methyl-7-vinyl-4,5-dihydro-2H-benzo[g]indazol-3-yl)-5-phenyl-4-(trifluoromethyl)isoxazoleHCID 866698863-(4-Isobutyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

Product 1

HCID 866699202-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydro-2H-benzo[g]indazole-7-carbaldehyde

Procedure

This compound was prepared according to the general procedure described for Preparation 23D, employing 240 mgs of 3-(2-methyl-7-vinyl-4,5-dihydro-2H-benzo[g]indazol-3-yl)-5-phenyl-4-(trifluoromethyl)isoxazole (79B). Yield: 235 mgs (97%); LC/MS M+1=424.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-e251241a7acf420ca1dea6a4667371e0
Source dataset
uspto-grants-2015_12
Patent number
US09216972B2

Reaction notes

Loading…