3-(2-methyl-7-vinyl-4,5-dihydro-2H-benzo[g]indazol-3-yl)-5-phenyl-4-(trifluoromethyl)isoxazole → 2-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydro-2H-benzo[g]indazole-7-carbaldehyde

Participants

Role	Name	HCID	Charge
Reactant	3-(2-methyl-7-vinyl-4,5-dihydro-2H-benzo[g]indazol-3-yl)-5-phenyl-4-(trifluoromethyl)isoxazole	HCID 67168991	—
Reactant	3-(4-Isobutyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde	HCID 86669886	—
Product	2-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydro-2H-benzo[g]indazole-7-carbaldehyde	HCID 86669920	—

Reaction Steps

This compound was prepared according to the general procedure described for Preparation 23D, employing 240 mgs of 3-(2-methyl-7-vinyl-4,5-dihydro-2H-benzo[g]indazol-3-yl)-5-phenyl-4-(trifluoromethyl)isoxazole (79B). Yield: 235 mgs (97%); LC/MS M+1=424.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09216972B2
Source dataset	uspto-grants-2015_12
ORD ID	ord-e251241a7acf420ca1dea6a4667371e0
Source note	uspto-grants-2015_12