Methyl 3,4-diethoxybenzoate → 3-(3,4-Diethoxyphenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

HRID 1506475Notes

Reaction equation

HRID 1506475 reaction equation
C(C1C=CC(C2ON=C3C4C(CCC=23)=CC(C=C)=CC=4)=CC=1C(F)(F)F)C(C)C.[CH:30]([C:32]1[CH:33]=[C:34]2[C:39](=[CH:40][CH:41]=1)[C:38](=[N:42][OH:43])[CH2:37][CH2:36][CH2:35]2)=[CH2:31].[CH2:44]([O:46][C:47]1[CH:48]=[C:49]([CH:54]=[CH:55][C:56]=1[O:57][CH2:58][CH3:59])[C:50](OC)=O)[CH3:45]>>[CH2:44]([O:46][C:47]1[CH:48]=[C:49]([C:50]2[O:43][N:42]=[C:38]3[C:39]4[C:34]([CH2:35][CH2:36][C:37]=23)=[CH:33][C:32]([CH:30]=[CH2:31])=[CH:41][CH:40]=4)[CH:54]=[CH:55][C:56]=1[O:57][CH2:58][CH3:59])[CH3:45]

Participants

4

Reactant 3

HCID 13652158Methyl 3,4-diethoxybenzoateHCID 671691843-(4-Isobutyl-3-(trifluoromethyl)phenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazoleHCID 866698666-vinyl-3,4-dihydronaphthalen-1(2H)-one oxime

Product 1

HCID 671702973-(3,4-Diethoxyphenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

Procedure

This compound was prepared according to the general procedure described for Preparation 23C, employing 200 mgs of 6-vinyl-3,4-dihydronaphthalen-1(2H)-one oxime (I-1) and methyl 3,4-diethoxybenzoate (1 eq). Yield: 217 mgs (25%); LC/MS M+1=362.1.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-63477ac5175c40a48a03595f9887ce66
Source dataset
uspto-grants-2015_12
Patent number
US09216972B2

Reaction notes

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