3-Phenyl-4-(trifluoromethyl)-5-(7-vinyl-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)isoxazole → 5-(7-(Oxiran-2-yl)-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole

HRID 1506483Notes

Reaction equation

HRID 1506483 reaction equation
[O:1]1CC1C1C=C2C(=CC=1)C1=NOC(C3C(C(F)(F)F)=C(C4C=CC=CC=4)ON=3)=C1CC2.[C:32]1([C:38]2[C:42]([C:43]([F:46])([F:45])[F:44])=[C:41]([C:47]3[S:48][C:49]4[C:59]5[C:54](=[CH:55][C:56]([CH:60]=[CH2:61])=[CH:57][CH:58]=5)[CH2:53][CH2:52][C:50]=4[N:51]=3)[O:40][N:39]=2)[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[O:1]1[CH2:61][CH:60]1[C:56]1[CH:55]=[C:54]2[C:59](=[CH:58][CH:57]=1)[C:49]1[S:48][C:47]([C:41]3[O:40][N:39]=[C:38]([C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=4)[C:42]=3[C:43]([F:46])([F:44])[F:45])=[N:51][C:50]=1[CH2:52][CH2:53]2

Participants

3

Reactant 2

HCID 671705843-Phenyl-4-(trifluoromethyl)-5-(7-vinyl-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)isoxazoleHCID 866698787-(Oxiran-2-yl)-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazole

Product 1

HCID 866699255-(7-(Oxiran-2-yl)-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole

Procedure

This compound was prepared according to the procedure described for Preparation 13A, employing 100 mgs of 3-phenyl-4-(trifluoromethyl)-5-(7-vinyl-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)isoxazole (82E). Yield: 100 mgs (96%)

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-d8d50049eb45474399c9d1f355ddca99
Source dataset
uspto-grants-2015_12
Patent number
US09216972B2

Reaction notes

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