N-(6-bromo-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)hexanamide → 7-Bromo-2-pentyl-4,5-dihydronaphtho[2,1-d]thiazole

HRID 1506490Notes

Reaction equation

HRID 1506490 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[C:11]1[S:10][C:9]([C:15]3ON=[C:17]([C:20]4C=CC=C[CH:21]=4)[C:16]=3C(F)(F)F)=[N:8][C:7]=1[CH2:6][CH2:5]2.BrC1C=C2C(=CC=1)C(=O)C(NC(=O)CCCCC)CC2>>[Br:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[C:11]1[S:10][C:9]([CH2:15][CH2:16][CH2:17][CH2:20][CH3:21])=[N:8][C:7]=1[CH2:6][CH2:5]2

Participants

3

Reactant 2

HCID 67168280N-(6-bromo-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)hexanamideHCID 671714645-(7-Bromo-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole

Product 1

HCID 681820787-Bromo-2-pentyl-4,5-dihydronaphtho[2,1-d]thiazole

Procedure

This compound was prepared according to the procedure described for Preparation 82D, employing 1.25 g of N-(6-bromo-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)hexanamide (86A). Yield: (415 mgs, 33%). LC/MS M+1=337.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-94f82244044a43289986d1912ae49821
Source dataset
uspto-grants-2015_12
Patent number
US09216972B2

Reaction notes

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