3-(4-Cyclohexyl-3-(trifluoromethyl)phenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole → 3-(4-Cyclohexyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

HRID 1506528Notes

Reaction equation

HRID 1506528 reaction equation
C1(N2C(C(F)(F)F)=C(C3[O:20]N=C4C5C(CCC=34)=CC(C=O)=CC=5)C=N2)C=CC=CC=1.[CH:31]1([C:37]2[CH:42]=[CH:41][C:40]([C:43]3[O:47][N:46]=[C:45]4[C:48]5[C:53]([CH2:54][CH2:55][C:44]=34)=[CH:52][C:51]([CH:56]=C)=[CH:50][CH:49]=5)=[CH:39][C:38]=2[C:58]([F:61])([F:60])[F:59])[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1>>[CH:31]1([C:37]2[CH:42]=[CH:41][C:40]([C:43]3[O:47][N:46]=[C:45]4[C:48]5[C:53]([CH2:54][CH2:55][C:44]=34)=[CH:52][C:51]([CH:56]=[O:20])=[CH:50][CH:49]=5)=[CH:39][C:38]=2[C:58]([F:59])([F:60])[F:61])[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]1

Participants

3

Reactant 2

HCID 671709843-(4-Cyclohexyl-3-(trifluoromethyl)phenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazoleHCID 866699303-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

Product 1

HCID 866699333-(4-Cyclohexyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

Procedure

The titled compound was prepared using the experimental protocol described for Preparation 89B employing 3-(4-cyclohexyl-3-(trifluoromethyl)phenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole (118D) as a starting material. The compound had an HPLC retention time=4.43 min. (condition C); LC/MS M+1=426.2.

Sources & evidence

ORD record
ord-9353bc5fed3243dc9a58f90d5859a07c
Source dataset
uspto-grants-2015_12
Patent number
US09216972B2

Reaction notes

Loading…