Ethyl 2-(diphenylmethyleneamino)-2-methyl-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate → Ethyl 2-(diphenylmethyleneamino)-2-methyl-4-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)butanoate
Reaction equation
[C:1]1([C:7](=[N:14][C:15]([CH3:51])([CH2:21][CH2:22][C:23]2[CH:24]=[C:25]3[C:48](=[CH:49][CH:50]=2)[C:29]2=NOC(C4C(C(F)(F)F)=C(C5C=CC=CC=5)ON=4)=[C:28]2[CH2:27][CH2:26]3)[C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(C(=NC(CCC2C=C3C(=CC=2)C2[S:82][C:81]([C:87]4[O:91][N:90]=[C:89]([C:92]5[CH:97]=[CH:96][CH:95]=[CH:94][CH:93]=5)[C:88]=4[C:98]([F:101])([F:100])[F:99])=[N:80]C=2CC3)C(OCC)=O)C2C=CC=CC=2)C=CC=CC=1>>[C:8]1([C:7](=[N:14][C:15]([CH3:51])([CH2:21][CH2:22][C:23]2[CH:24]=[C:25]3[C:48](=[CH:49][CH:50]=2)[C:29]2[S:82][C:81]([C:87]4[O:91][N:90]=[C:89]([C:92]5[CH:97]=[CH:96][CH:95]=[CH:94][CH:93]=5)[C:88]=4[C:98]([F:101])([F:100])[F:99])=[N:80][C:28]=2[CH2:27][CH2:26]3)[C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1Participants
3
Reactant 2
Product 1
Procedure
The titled compound was prepared using the experimental protocol described for Preparation 93A employing ethyl 2-(diphenylmethyleneamino)-4-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)butanoate (Preparation 119A) as a starting material. The compound had an LC/MS M+1=706.4.
Sources & evidence
- ORD record
- ord-cf746641c0d24e84bfbc5b8803084826
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09216972B2
Reaction notes
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