3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole → HCID 67171291, compound

HRID 1506538Notes

Reaction equation

HRID 1506538 reaction equation
C1(N2C(C(F)(F)F)=C(C3ON=C4C5C(CCC=34)=CC(C=C)=CC=5)C=N2)C=CC=CC=1.[CH:31]([C:33]1[CH:34]=[C:35]2[C:40](=[CH:41][CH:42]=1)[C:39](=[N:43][OH:44])[CH2:38][CH2:37][CH2:36]2)=[CH2:32].[F:45][C:46]1[CH:47]=[CH:48][C:49]([N:52]2[C:56]([C:57]([F:60])([F:59])[F:58])=[C:55]([C:61](OCC)=O)[CH:54]=[N:53]2)=[N:50][CH:51]=1>>[F:45][C:46]1[CH:47]=[CH:48][C:49]([N:52]2[C:56]([C:57]([F:60])([F:59])[F:58])=[C:55]([C:61]3[O:44][N:43]=[C:39]4[C:40]5[C:35]([CH2:36][CH2:37][C:38]=34)=[CH:34][C:33]([CH:31]=[CH2:32])=[CH:42][CH:41]=5)[CH:54]=[N:53]2)=[N:50][CH:51]=1

Participants

4

Reactant 3

HCID 671704203-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazoleHCID 67171373ethyl 1-(5-fluoropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylateHCID 866698666-vinyl-3,4-dihydronaphthalen-1(2H)-one oxime

Product 1

HCID 67171291HCID 67171291, compound

Procedure

The titled compound was prepared using the experimental protocol described for Preparation 89A employing 6-vinyl-3,4-dihydronaphthalen-1(2H)-one oxime (I-1) and ethyl 1-(5-fluoropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (Preparation 122A) as starting materials. The compound had an HPLC retention time=3.93 min. (condition C); LC/MS M+1=426.9.

Sources & evidence

ORD record
ord-fb6490b76b7e416eabe0ff43714b7fde
Source dataset
uspto-grants-2015_12
Patent number
US09216972B2

Reaction notes

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