HCID 67171291, compound → 3-(1-(5-fluoropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

HRID 1506539Notes

Reaction equation

HRID 1506539 reaction equation
C1(N2C(C(F)(F)F)=C(C3[O:20]N=C4C5C(CCC=34)=CC(C=O)=CC=5)C=N2)C=CC=CC=1.[F:31][C:32]1[CH:33]=[CH:34][C:35]([N:38]2[C:42]([C:43]([F:46])([F:45])[F:44])=[C:41]([C:47]3[O:51][N:50]=[C:49]4[C:52]5[C:57]([CH2:58][CH2:59][C:48]=34)=[CH:56][C:55]([CH:60]=C)=[CH:54][CH:53]=5)[CH:40]=[N:39]2)=[N:36][CH:37]=1>>[F:31][C:32]1[CH:33]=[CH:34][C:35]([N:38]2[C:42]([C:43]([F:46])([F:45])[F:44])=[C:41]([C:47]3[O:51][N:50]=[C:49]4[C:52]5[C:57]([CH2:58][CH2:59][C:48]=34)=[CH:56][C:55]([CH:60]=[O:20])=[CH:54][CH:53]=5)[CH:40]=[N:39]2)=[N:36][CH:37]=1

Participants

3

Reactant 2

HCID 67171291HCID 67171291, compoundHCID 866699303-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

Product 1

HCID 866699373-(1-(5-fluoropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

Procedure

The titled compound was prepared using the experimental protocol described for Preparation 89B employing 3-(1-(5-fluoropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole (122B) as a starting material. The compound had an HPLC retention time=3.56 min. (condition C); LC/MS M+1=428.9.

Sources & evidence

ORD record
ord-f93097884c174c998ad0f4a832031c34
Source dataset
uspto-grants-2015_12
Patent number
US09216972B2

Reaction notes

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