Benzoic Acid → Bromhexine

HRID 1506608Notes

Reaction equation

HRID 1506608 reaction equation
[CH3:1][N:2]([CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)[CH2:3][C:4]1[CH:5]=[C:6]([Br:12])[CH:7]=[C:8]([Br:11])[C:9]=1[NH2:10].Cl.C(O)[C@H]1O[C@H](O[C@@H]([C@H](O)[C@@H](O)CO)[C@H](O)CO)[C@H](O)[C@@H](O)[C@@H]1O.C(O)(=O)C1C=CC=CC=1>O>[CH3:1][N:2]([CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)[CH2:3][C:4]1[C:9]([NH2:10])=[C:8]([Br:11])[CH:7]=[C:6]([Br:12])[CH:5]=1

Participants

5

Reactant 3

HCID 243Benzoic AcidHCID 493591MaltitolHCID 5702220Bromhexine hydrochloride

Product 1

HCID 2442Bromhexine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Composition: bromhexine hydrochloride (0.16 g/100 ml), maltitol liquid (50 g), benzoic acid (0.13 g/100 ml), flavourings, water.

Sources & evidence

ORD record
ord-38751b24b45d44c684ac000393dc795a
Source dataset
uspto-grants-2015_12
Patent number
US09220693B2

Reaction notes

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