Hydrogen Bromide → 5-Bromo-3-Methylpentanoic Acid

A solution of β-methyl-δ-valerolactone (3.0 g) in anhydrous dichloromethane (30 ml), cooled to 0-5° C., was saturated with hydrogen bromide gas and the mixture was stirred for three days at room temperature. The mixture was diluted with dichloromethane (100 ml) and the resulting solution was washed with 10-% NaCl (3×30 ml). Next the solution was dried with anhydrous MgSO4 and the solvent was distilled under reduced pressure, Yield: 4.6 g. NMR ˜100% pure product.

1. washthe resulting solution was washed with 10-% NaCl (3×30 ml)
2. dry with materialNext the solution was dried with anhydrous MgSO4
3. distillationthe solvent was distilled under reduced pressure, Yield: 4.6 g

ORD record

ord-0fffdb26341f467086ab220ecc0b09d0

Source dataset

uspto-grants-2015_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09220790B2