HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-1-(1H-imidazol-2-yl)-2-phenylethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | [(S)-1-(1H-imidazol-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester | HCID 57976325 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-1-(1H-imidazol-2-yl)-2-phenylethanamine | HCID 54484811 | — |
Reaction Steps
(S)-tert-Butyl 1-(1H-imidazol-2-yl)-2-phenylethylcarbamate (355 mg, 1.18 mmol) was dissolved in DCM (5 mL) and treated with 4N HCl in dioxanes (12 mL). After 3 hr, solvents were removed in vacuo and the crude product was used directly in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09220710B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-3f320343467a4a2e94b92aafa77a7e40 |
| Source note | uspto-grants-2015_12 |