Hydrochloric Acid → (S)-1-(1H-imidazol-2-yl)-2-phenylethanamine

HRID 1506616Notes

Reaction equation

HRID 1506616 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C@@H:6]([NH:14]C(=O)OC(C)(C)C)[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.Cl>C(Cl)Cl>[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C@@H:6]([NH2:14])[CH2:7][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57976325[(S)-1-(1H-imidazol-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

Product 1

HCID 54484811(S)-1-(1H-imidazol-2-yl)-2-phenylethanamine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(S)-tert-Butyl 1-(1H-imidazol-2-yl)-2-phenylethylcarbamate (355 mg, 1.18 mmol) was dissolved in DCM (5 mL) and treated with 4N HCl in dioxanes (12 mL). After 3 hr, solvents were removed in vacuo and the crude product was used directly in the next reaction.

Workup

  1. customsolvents were removed in vacuo
  2. customthe crude product was used directly in the next reaction

Sources & evidence

ORD record
ord-3f320343467a4a2e94b92aafa77a7e40
Source dataset
uspto-grants-2015_12
Patent number
US09220710B2

Reaction notes

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