Hydrochloric Acid → (S)-1-(1-(2-methoxybenzyl)-1H-imidazol-2-yl)-2-phenylethanamine

HRID 1506621Notes

Reaction equation

HRID 1506621 reaction equation
[CH3:1][O:2][C:3]1[CH:30]=[CH:29][CH:28]=[CH:27][C:4]=1[CH2:5][N:6]1[CH:10]=[CH:9][N:8]=[C:7]1[C@@H:11]([NH:19]C(=O)OC(C)(C)C)[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.Cl>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:30]=[CH:29][CH:28]=[CH:27][C:4]=1[CH2:5][N:6]1[CH:10]=[CH:9][N:8]=[C:7]1[C@@H:11]([NH2:19])[CH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90281194(S)-tert-butyl 1-(1-(2-methoxybenzyl)-1H-imidazol-2-yl)-2-phenylethylcarbamate

Product 1

HCID 90281302(S)-1-(1-(2-methoxybenzyl)-1H-imidazol-2-yl)-2-phenylethanamine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(S)-tert-butyl 1-(1-(2-methoxybenzyl)-1H-imidazol-2-yl)-2-phenylethylcarbamate was dissolved in DCM and treated with 4 N HCl in dioxanes. The reaction was stirred for 3 hr. Solvents were removed in vacuo to provide the desired product. MS (m/z) 308.1 [M+H]+.

Workup

  1. customSolvents were removed in vacuo

Sources & evidence

ORD record
ord-54727a47348e492bb24cb0300b167e44
Source dataset
uspto-grants-2015_12
Patent number
US09220710B2

Reaction notes

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