HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetohydrazide → ethyl 5-methyl-4-(o-tolyl)-4H-1,2,4-triazole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetohydrazide | HCID 14039 | — |
| Reactant | Ethyl 2-chloro-2-(o-tolylimino)acetate | HCID 90280270 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | ethyl 5-methyl-4-(o-tolyl)-4H-1,2,4-triazole-3-carboxylate | HCID 90281310 | — |
Reaction Steps
The suspension of 10B and acetohydrazide in acetonitrile was refluxed for 2 hours. The solvent was removed. The crude product was purified by flash column (Rf: 0.2, 50% EtOAc/Hexanes). MS (m/z) 246 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09220710B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-c87dde1f99f74e8ab8144f3ed86247ae |
| Source note | uspto-grants-2015_12 |