(NZ)-N-[[2-(4-chlorophenyl)-1,3-oxazol-5-yl]methylidene]-2-methylpropane-2-sulfinamide → 1-(2-(4-Chlorophenyl)oxazol-5-yl)-2-(3,5-difluorophenyl)ethanamine hydrochloride

HRID 1506643Notes

Reaction equation

HRID 1506643 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C@@H:10]([C:12]2N(C3C=CC(OC)=CC=3)C=CN=2)[NH2:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]2[O:33]C(/C=N\S(C(C)(C)C)=O)=[CH:35][N:36]=2)=[CH:28][CH:27]=1>>[ClH:25].[Cl:25][C:26]1[CH:27]=[CH:28][C:29]([C:32]2[O:33][C:12]([CH:10]([NH2:11])[CH2:9][C:4]3[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([F:1])[CH:3]=3)=[CH:35][N:36]=2)=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 90280405(NZ)-N-[[2-(4-chlorophenyl)-1,3-oxazol-5-yl]methylidene]-2-methylpropane-2-sulfinamideHCID 90281432(S)-2-(3,5-difluorophenyl)-1-(1-(4-methoxyphenyl)-1H-imidazol-2-yl)ethanamine

Product 1

HCID 902803201-(2-(4-Chlorophenyl)oxazol-5-yl)-2-(3,5-difluorophenyl)ethanamine hydrochloride

Procedure

The title compound was prepared according to the method presented for the synthesis of compound 5E of Example 5 utilizing 19D. MS (m/z) 335.2 [M+H]+.

Sources & evidence

ORD record
ord-fe89d246894a4f5686e66e8d8443319d
Source dataset
uspto-grants-2015_12
Patent number
US09220710B2

Reaction notes

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