(NE)-N-[[5-(4-chlorophenyl)-1,3-oxazol-4-yl]methylidene]-2-methylpropane-2-sulfinamide → N-(1-(5-(4-chlorophenyl)oxazol-4-yl)-2-(3,5-difluorophenyl)ethyl)-2-methylpropane-2-sulfinamide

HRID 1506663Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1506663
COC1C=CC(N2C=CN=C2C=N[S@@](C(C)(C)C)=O)=CC=1.[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[O:33][CH:32]=[N:31][C:30]=2/[CH:34]=[N:35]/[S:36]([C:38]([CH3:41])([CH3:40])[CH3:39])=[O:37])=[CH:25][CH:24]=1.[F:42][C:43]1[CH:44]=[C:45]([CH:49]=[C:50]([F:52])[CH:51]=1)[CH2:46][Mg]Br>>[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[O:33][CH:32]=[N:31][C:30]=2[CH:34]([NH:35][S:36]([C:38]([CH3:41])([CH3:40])[CH3:39])=[O:37])[CH2:46][C:45]2[CH:44]=[C:43]([F:42])[CH:51]=[C:50]([F:52])[CH:49]=2)=[CH:25][CH:24]=1

Komponenten

4

Edukt 3

HCID 90280296(NE)-N-[[5-(4-chlorophenyl)-1,3-oxazol-4-yl]methylidene]-2-methylpropane-2-sulfinamideHCID 90281518(R)-N-((1-(4-methoxyphenyl)-1H-imidazol-2-yl)methylene)-2-methylpropane-2-sulfinamideHCID 178505920HCID 178505920, Verbindung

Produkt 1

HCID 90280394N-(1-(5-(4-chlorophenyl)oxazol-4-yl)-2-(3,5-difluorophenyl)ethyl)-2-methylpropane-2-sulfinamide

Versuchsvorschrift

The title compound was prepared as a mixture of diastereomers according to the method presented for the synthesis of compound 5C and 5D of Example 5 utilizing 33E and (3,5-difluorobenzyl)magnesium bromide. MS (m/z) 438.9 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-990c647ecb61421cbe744c97d5cfcaca
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09220710B2

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