4-(4-fluorobenzyloxy)-1-(4-hydroxyphenyl)-1H-pyrimidin-2-one → 4-(4-fluorobenzyloxy)-1-{4-[2-(1-pyrrolidinyl)-ethoxy]phenyl}-1H-pyrimidin-2-one

HRID 15067Notes

Reaction equation

HRID 15067 reaction equation
C(OC1[CH:14]=[CH:13][N:12]([C:15]2[CH:20]=[CH:19][C:18](O)=CC=2)C(=O)C=1)C1C=CC=CC=1.[F:23][C:24]1[CH:45]=[CH:44][C:27]([CH2:28][O:29][C:30]2[CH:35]=[CH:34][N:33]([C:36]3[CH:41]=[CH:40][C:39]([OH:42])=[CH:38][CH:37]=3)[C:32](=[O:43])[N:31]=2)=[CH:26][CH:25]=1>>[F:23][C:24]1[CH:25]=[CH:26][C:27]([CH2:28][O:29][C:30]2[CH:35]=[CH:34][N:33]([C:36]3[CH:41]=[CH:40][C:39]([O:42][CH2:14][CH2:13][N:12]4[CH2:15][CH2:20][CH2:19][CH2:18]4)=[CH:38][CH:37]=3)[C:32](=[O:43])[N:31]=2)=[CH:44][CH:45]=1

Participants

3

Reactant 2

HCID 684303764-(4-fluorobenzyloxy)-1-(4-hydroxyphenyl)-1H-pyrimidin-2-oneHCID 684312834-benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one

Product 1

HCID 117042274-(4-fluorobenzyloxy)-1-{4-[2-(1-pyrrolidinyl)-ethoxy]phenyl}-1H-pyrimidin-2-one

Procedure

Step (3) of Example 12 was repeated except that 4-benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one was replaced with 4-(4-fluorobenzyloxy)-1-(4-hydroxyphenyl)-1H-pyrimidin-2-one, to provide the title compound.

Sources & evidence

ORD record
ord-a9f8ad2f3b384e12a6b369833d155a12
Source dataset
uspto-grants-2010_06
Patent number
US07732456B2

Reaction notes

Loading…