HCID 70982893, compound → 4-(Pyrrolidin-1-yl)butan-1-amine

HRID 1506752Notes

Reaction equation

HRID 1506752 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][CH2:9][NH:10]C(=O)OCC2C=CC=CC=2)[CH2:5][CH2:4][CH2:3][CH2:2]1>[Pd]>[N:1]1([CH2:6][CH2:7][CH2:8][CH2:9][NH2:10])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 1

HCID 70982893HCID 70982893, compound

Product 1

HCID 27627624-(Pyrrolidin-1-yl)butan-1-amineYield 82.2%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

To a solution of benzyl 4-(pyrrolidin-1-yl)butylcarbamate (196 mg, 0.71 mmol) was added catalytic amount of Pd/C (5%). The reaction was stirred under a hydrogen atmosphere overnight and filtered. The filtrate was concentrated to give 4-(pyrrolidin-1-yl)butan-1-amine (83 mg)

Workup

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-4bdf11b76ca04cc290690068dd55cd3a
Source dataset
uspto-grants-2015_12
Patent number
US09221760B2

Reaction notes

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