3,9-Dichloro-7-methoxyacridine → HCID 71471685, compound

HRID 1506765Notes

Reaction equation

HRID 1506765 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:13](=[CH:14][CH:15]=1)[C:12](Cl)=[C:11]1[C:6]([CH:7]=[CH:8][C:9]([O:17][CH3:18])=[CH:10]1)=[N:5]2.Cl.[CH:20]1([N:23]([CH2:29][CH3:30])[CH2:24][CH2:25][CH2:26][CH2:27][NH2:28])[CH2:22][CH2:21]1.C(N(C(C)C)CC)(C)C>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:13](=[CH:14][CH:15]=1)[C:12]([NH:28][CH2:27][CH2:26][CH2:25][CH2:24][N:23]([CH:20]1[CH2:22][CH2:21]1)[CH2:29][CH3:30])=[C:11]1[C:6]([CH:7]=[CH:8][C:9]([O:17][CH3:18])=[CH:10]1)=[N:5]2

Participants

4

Reactant 3

HCID 665773,9-Dichloro-7-methoxyacridineHCID 81531DiisopropylethylamineHCID 86720060HCID 86720060, compound

Product 1

HCID 71471685HCID 71471685, compound

Procedure

Following the general procedure of Example 1 and making non-critical variations but using 6,9-dichloro-2-methoxyacridine, N1-cyclopropyl-N1-ethylbutane-1,4-diamine HCl salt (Step 2) and diisopropyethylamine (4 eq), the title compound was obtained; MS (Found M+1=398).

Sources & evidence

ORD record
ord-af0e9e8eab3447ab9ddd0b2cfcc7689a
Source dataset
uspto-grants-2015_12
Patent number
US09221760B2

Reaction notes

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