Ammonia → 4-[4-((R)-3-Amino-2-hydroxy-propylamino)-phenyl]-morpholin-3-one hydrochloride
Reaction equation
[Cl:1][CH2:2][C@H:3]([OH:19])[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][C:13]2=[O:18])=[CH:8][CH:7]=1.[NH3:20].C>>[ClH:1].[NH2:20][CH2:2][C@@H:3]([OH:19])[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][C:13]2=[O:18])=[CH:8][CH:7]=1Participants
Procedure
30.00 g of 4-[4-((R)-3-chloro-2-hydroxy-propylamino)-phenyl]-morpholin-3-one (CHP-APMO) (MW=284.75; 1 eq.) were added to 1298 g of conc. aqueous ammonia (MW 17.03; 181 eq.). The reaction mixture was stirred for 2.5 h at room temperature. Then 3.0 g of charcoal were added and after 10 min of stirring, the suspension was filtered and the cake was washed with 90 mL of water. Filtrate and wash water were combined and concentrated in vacuo to a mass of 37 g. To the residue were added 107 mL of ethanol. The resulting suspension was stirred for 1 h at ambient temperature and then cooled to 0° C. After stirring for at least 2 h at this temperature, the product was isolated by filtration and the filter cake was washed with 75 mL of ethanol. After drying in vacuo at 30° C., 23.98 g of the crystalline title compound were isolated. Yield=75.4%.
Workup
- stirringof stirring
- filtrationthe suspension was filtered
- washthe cake was washed with 90 mL of water
- washFiltrate and wash water
- concentrationconcentrated in vacuo to a mass of 37 g
- additionTo the residue were added 107 mL of ethanol
- stirringThe resulting suspension was stirred for 1 h at ambient temperature
- temperaturecooled to 0° C
- stirringAfter stirring for at least 2 h at this temperature
- customthe product was isolated by filtration
- washthe filter cake was washed with 75 mL of ethanol
- customAfter drying in vacuo at 30° C.
Sources & evidence
- ORD record
- ord-f1a574217f904a67b59ccdf8597d05c5
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09221771B2
Reaction notes
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