4-Iodobenzoic acid → HCID 71656519, compound

HRID 1506843Notes

Reaction equation

HRID 1506843 reaction equation
[I:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.IC1C=CC(C(O)=O)=CC=1.S(Cl)(Cl)=O.[CH2:25]([C:29]1[O:30][C:31]2[CH:37]=[CH:36][C:35]([NH:38][S:39]([CH3:42])(=[O:41])=[O:40])=[CH:34][C:32]=2[CH:33]=1)[CH2:26][CH2:27][CH3:28]>ClCCl>[CH2:25]([C:29]1[O:30][C:31]2[CH:37]=[CH:36][C:35]([NH:38][S:39]([CH3:42])(=[O:40])=[O:41])=[CH:34][C:32]=2[C:33]=1[C:6](=[O:7])[C:5]1[CH:9]=[CH:10][C:2]([I:1])=[CH:3][CH:4]=1)[CH2:26][CH2:27][CH3:28]

Participants

6

Reactant 4

HCID 120854-Iodobenzoic acidHCID 24386Thionyl ChlorideHCID 743734-Iodobenzoyl chlorideHCID 9878493N-(2-Butyl-1-benzofuran-5-yl)methanesulfonamide

Product 1

HCID 71656519HCID 71656519, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

6.12 g of 4-iodobenzoyl chloride—prepared by reacting 4-iodobenzoic acid with thionyl chloride—and 5.42 g of 2-butyl-5-methanesulfonamido-benzofuran (IV) were dissolved in 30 ml of dichloromethane. The reaction was performed according to Example 10.

Sources & evidence

ORD record
ord-cc856a91027b4058a676d10da51f116c
Source dataset
uspto-grants-2015_12
Patent number
US09221777B2

Reaction notes

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