反应详情

A suspension of compound (20) (0.78 g, 2.82 mmol), ethyl 2-methyl-3-oxopentanoate (0.46 mL, 2.82 mmol) and anhydrous potassium carbonate (0.70 g, 5.1 mmol) in acetone (40 mL) was allowed to react in the same manner as in Example 15. The obtained residue was subjected to silica gel column chromatography and elution with an n-hexane/ethyl acetate (7:2) solution followed by conventional decarboxylation and hydrolysis to give 0.53 g (53%) of compound (24) of interest as clear colorless oil.

1. customto react in the same manner as in Example 15
2. washThe obtained residue was subjected to silica gel column chromatography and elution with an n-hexane/ethyl acetate (7:2) solution
3. customfollowed by conventional decarboxylation and hydrolysis