Water → 2-(2,6-Difluoro-4-nitrophenyl)propanoic acid

HRID 1506879Notes

Reaction equation

HRID 1506879 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[C:4]([F:11])[C:3]=1[C:12](C)([C:18](OCC)=O)[C:13]([O:15]CC)=[O:14].S(=O)(=O)(O)O.O>C(O)(=O)C>[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[C:4]([F:11])[C:3]=1[CH:12]([CH3:18])[C:13]([OH:15])=[O:14]

Participants

5

Reactant 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 58280423HCID 58280423, compound

Product 1

HCID 534295682-(2,6-Difluoro-4-nitrophenyl)propanoic acidYield 85.1%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of compound (26b) (7.8 g, 24.9 mmol) in acetic acid (28 mL), and concentrated sulfuric acid (8.0 mL), and water (20 mL) were treated in the same manner as in (b) in Production Example 1 to give 4.9 g (85%) of compound (27b) as yellow solid.

Sources & evidence

ORD record
ord-97e23ef791194846ab73cdd4db5bd356
Source dataset
uspto-grants-2015_12
Patent number
US09221786B2

Reaction notes

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