Hydrochloric Acid → 1383372-63-1

HRID 1506941Notes

Reaction equation

HRID 1506941 reaction equation
[CH2:1]([C:8]1([OH:19])[CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:20]>>[ClH:20].[CH2:1]([C:8]1([OH:19])[CH2:11][NH:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 659192071383372-62-0

Product 1

HCID 679741631383372-63-1Yield 90%

Procedure

tert-butyl 3-benzyl-3-hydroxyazetidine-1-carboxylate 3 (2.0 gm, 7.59 mmol) was taken into a round bottomed flask and was added methanolic-HCl (25 mL, 20%) and was stirred for 3 h at room temperature. After completion of the reaction (monitored by TLC), the solvent was removed under vacuum to get a white solid as a crude product. The crude product was washed with ethyl acetate repeatedly and then dried well to obtain compound 4 as a white solid (1.36 gm, 90%) which was used without further purification.

Workup

  1. customAfter completion of the reaction (monitored by TLC)
  2. customthe solvent was removed under vacuum
  3. customto get a white solid as a crude product
  4. washThe crude product was washed with ethyl acetate repeatedly
  5. customdried well

Sources & evidence

ORD record
ord-39e1016e19104652872b2cb2f596365e
Source dataset
uspto-grants-2015_12
Patent number
US09221792B2

Reaction notes

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