Hydrochloric Acid → 3-(Benzyloxy)azetidine hydrochloride

HRID 1506945Notes

Reaction equation

HRID 1506945 reaction equation
[CH2:1]([O:8][CH:9]1[CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:20]>>[ClH:20].[CH2:1]([O:8][CH:9]1[CH2:10][NH:11][CH2:12]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 10587639HCID 10587639, compound

Product 1

HCID 467370113-(Benzyloxy)azetidine hydrochlorideYield 92%

Procedure

tert-butyl 3-(benzyloxy)azetidine-1-carboxylate 23 (1.0 gm) was taken into a round bottomed flask and was added methanolic-HCl (15 mL, 20%) and was stirred for 1 h at room temperature. After completion of the reaction (monitored by TLC), the solvent was removed under vacuum to get a white solid as a crude product. The crude product was washed with ethyl acetate repeatedly and then dried well to obtain compound 24 as a white solid (92%) and was used further without purification.

Workup

  1. customAfter completion of the reaction (monitored by TLC)
  2. customthe solvent was removed under vacuum
  3. customto get a white solid as a crude product
  4. washThe crude product was washed with ethyl acetate repeatedly
  5. customdried well

Sources & evidence

ORD record
ord-7d1c1884c08f46b0b21185e190766b63
Source dataset
uspto-grants-2015_12
Patent number
US09221792B2

Reaction notes

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