HCID 123538816, compound → HCID 123785902, compound

HRID 1506980Notes

Reaction equation

HRID 1506980 reaction equation
[Si:1]([O:8][CH2:9][CH2:10][C@H:11]([OH:21])[C@H:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[Cl:20])[OH:13])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[Si](OCC[C@@H](O)[C@@H](C1C=CC=CC=1Cl)O)([C:25](C)([CH3:27])[CH3:26])(C)C>>[C:4]([Si:1]([O:8][CH2:9][CH2:10][C@H:11]1[C@H:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:20])[O:13][C:25]([CH3:27])([CH3:26])[O:21]1)([CH3:3])[CH3:2])([CH3:6])([CH3:7])[CH3:5]

Participants

3

Reactant 2

HCID 123538816HCID 123538816, compoundHCID 123891295HCID 123891295, compound

Product 1

HCID 123785902HCID 123785902, compoundYield 70%

Procedure

The substantially same method as described in Example 351 was conducted, except that (1S,2S)-4-(tert-butyldimethylsilyloxy)-1-(2-chlorophenyl)butane-1,2-diol (Preparation example 353) was used instead of 1R, 2R)-4-(tert-butyldimethylsilyloxy)-1-(2-chlorophenyl)butane-1,2-diol (Preparation example 349), to obtain the title compound (0.7 g, 70˜95%)

Sources & evidence

ORD record
ord-bc828c64523b4f679157506d111f26c4
Source dataset
uspto-grants-2015_12
Patent number
US09221783B2

Reaction notes

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