反应详情

温度

80 °C

To a solution of 2-(methylsulfonyl)phenol (100 mg, 0.58 mmol) and K2CO3 (276 mg, 2 mmol) in CH3CN (10 mL) was added ethyl 2-bromoacetate (115.2 mg, 0.69 mmol) at 25° C. The mixture was heated at 80° C. for 4 h, diluted with water and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate and concentrated. The crude product was used in the next step without further purification. (140 mg, yield 94%).

1. extractionextracted with ethyl acetate
2. washThe combined organic layers were washed with brine
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated
5. customThe crude product was used in the next step without further purification