2-Bromophenol → ethyl 2-(2-bromophenoxy)acetate

HRID 1507038Notes

Reaction equation

HRID 1507038 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].Br[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].C([O-])([O-])=O.[K+].[K+]>CC#N>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

5

Reactant 3

HCID 72442-BromophenolHCID 7748Ethyl bromoacetateHCID 11430Potassium Carbonate

Product 1

HCID 3310995ethyl 2-(2-bromophenoxy)acetate

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 2-bromophenol (2 g, 0.0116 mol) in MeCN (10 mL) was added ethyl bromoacetate (2.12 g, 0.0128 mol) and K2CO3 (4.81 g, 0.035 mol). The mixture was stirred at 80° C. for 4 h, filtered and concentrated. The crude product was used in the next step without further purification.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated
  3. customThe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-fa7e2465670049069b831b7414032f8d
Source dataset
uspto-grants-2015_12
Patent number
US09221794B2

Reaction notes

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