HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1507045Generated: October 30, 2026
8-Hydroxyquinoline → Ethyl (quinolin-8-yloxy)acetate
https://huagongshe.com/reaction/1507045
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 8-Hydroxyquinoline | HCID 1923 | — |
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ethyl (quinolin-8-yloxy)acetate | HCID 4379860 | 81% |
Reaction Steps
To a solution of quinolin-8-ol (3 g, 0.0207 mol) in MeCN (10 mL) was added ethyl bromoacetate (4.12 g, 0.025 mol) and K2CO3 (5.75 g, 0.0414 mol). The mixture was stirred at 80° C. for 12 h, filtered and concentrated. The residue was purified by column chromatography. (3.9 g, yield 81%) MS (ESI+) e/z: 232.1 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09221794B2 |
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| Source dataset | uspto-grants-2015_12 |
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| ORD ID | ord-d6ebff954b54486c918a6e66f85357f0 |
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| Source note | uspto-grants-2015_12 |
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