反应详情

温度

80 °C

To a solution of quinolin-8-ol (3 g, 0.0207 mol) in MeCN (10 mL) was added ethyl bromoacetate (4.12 g, 0.025 mol) and K2CO3 (5.75 g, 0.0414 mol). The mixture was stirred at 80° C. for 12 h, filtered and concentrated. The residue was purified by column chromatography. (3.9 g, yield 81%) MS (ESI+) e/z: 232.1 [M+1]+.

1. filtrationfiltered
2. concentrationconcentrated
3. customThe residue was purified by column chromatography