4-(4-fluorobenzyloxy)-1-(4-hydroxyphenyl)-1H-pyridin-2-one → HCID 58964877, compound

HRID 15071Notes

Reaction equation

HRID 15071 reaction equation
C(OC1C=CN(C2C=CC(O)=CC=2)C(=O)C=1)C1C=CC=CC=1.[F:23][C:24]1[CH:45]=[CH:44][C:27]([CH2:28][O:29][C:30]2[CH:35]=[CH:34][N:33]([C:36]3[CH:41]=[CH:40][C:39]([OH:42])=[CH:38][CH:37]=3)[C:32](=[O:43])[CH:31]=2)=[CH:26][CH:25]=1.[F:46][CH2:47][C@@H:48]1[CH2:52][CH2:51][CH2:50][N:49]1[CH2:53][CH2:54]O>>[F:23][C:24]1[CH:25]=[CH:26][C:27]([CH2:28][O:29][C:30]2[CH:35]=[CH:34][N:33]([C:36]3[CH:41]=[CH:40][C:39]([O:42][CH2:54][CH2:53][N:49]4[CH2:50][CH2:51][CH2:52][C@H:48]4[CH2:47][F:46])=[CH:38][CH:37]=3)[C:32](=[O:43])[CH:31]=2)=[CH:44][CH:45]=1

Participants

4

Reactant 3

HCID 674568224-(4-fluorobenzyloxy)-1-(4-hydroxyphenyl)-1H-pyridin-2-oneHCID 684311782-[(S)-2-fluoromethyl-1-pyrrolidinyl]ethanolHCID 684312834-benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one

Product 1

HCID 58964877HCID 58964877, compound

Procedure

Step (3) of Example 12 was repeated except that 4-benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one and 2-(1-pyrrolidine)ethanol were replaced with 4-(4-fluorobenzyloxy)-1-(4-hydroxyphenyl)-1H-pyridin-2-one (Step (2) of Example 28) and 2-[(S)-2-fluoromethyl-1-pyrrolidinyl]ethanol, respectively, to provide the title compound.

Sources & evidence

ORD record
ord-656d43bca27e48fc8c168823c40cbf39
Source dataset
uspto-grants-2010_06
Patent number
US07732456B2

Reaction notes

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