5-Aminopentan-1-ol → HCID 90374994, compound

HRID 1507155Notes

Reaction equation

HRID 1507155 reaction equation
[CH:1]([C:3]1[CH:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][N:4]=1)=O.[NH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][OH:20]>>[OH:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][NH:14][CH2:1][C:3]1[CH:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 756345-Aminopentan-1-olHCID 19600808Ethyl 2-formylpyridine-4-carboxylate

Product 1

HCID 90374994HCID 90374994, compound

Procedure

Prepared by General Procedure A from ethyl 2-formylpyridine-4-carboxylate (1.0 equiv.) and 5-aminopentan-1-ol (1.2 equiv.). Purification by column chromatography (DCM/MeOH (85:15) gave the title compound as greenish oil. 1H-NMR (300 MHz, CDCl3): δ 8.60 (d, 1H), 7.80 (s, 1H), 7.00 (d, 1H), 4.30 (q, 2H), 3.90 (s, 2H), 3.50 (t 2H), 3.10 (s, 2H), 2.60 (m, 2H), 1.50 (m, 4H), 1.30 (t, 3H) ppm.

Workup

  1. customPurification by column chromatography (DCM/MeOH (85:15)

Sources & evidence

ORD record
ord-15619c3703e84d2281f0ceb8882b8e67
Source dataset
uspto-grants-2015_12
Patent number
US09221801B2

Reaction notes

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