Hydrochloric Acid → HCID 118207414, compound

HRID 1507173Notes

Reaction equation

HRID 1507173 reaction equation
[ClH:1].O1CCOCC1.O[C:9]1([C:23]2[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=2)[CH2:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1>>[ClH:1].[CH3:30][O:29][C:26]1[CH:25]=[CH:24][C:23]([C:9]2[CH2:15][CH2:14][CH2:13][NH:12][CH2:11][CH:10]=2)=[CH:28][CH:27]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 118207413HCID 118207413, compound

Product 1

HCID 118207414HCID 118207414, compound

Procedure

A mixture of HCl in dioxane (10 mL, 40 mmol) and tert-butyl 4-hydroxy-4-(4-methoxyphenyl)azepane-1-carboxylate (0.68 g, 2.1 mmol) was stirred at room temperature for 3 h. The reaction mixture was concentrated and washed with diethyl ether and dried over sodium sulfate to yield 0.36 g 5-(4-methoxyphenyl)-2,3,4,7-tetrahydro-1H-azepine hydrochloride. LCMS: R.T. 0.61 min. LCMS (ES-API), m/z 204.0 (M+H).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. washwashed with diethyl ether
  3. dry with materialdried over sodium sulfate

Sources & evidence

ORD record
ord-4d978e843438478481e6fa987e777b03
Source dataset
uspto-grants-2015_12
Patent number
US09221796B2

Reaction notes

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