2,3-Dichloro-6-methoxyquinoline → Ethyl 4-(3-chloro-6-methoxyquinolin-2-yl)cyclohex-3-enecarboxylate

HRID 1507362Notes

Reaction equation

HRID 1507362 reaction equation
CC1(C)C(C)(C)OB([C:9]2[CH2:14][CH2:13][CH:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:11][CH:10]=2)O1.Cl[C:22]1[C:31]([Cl:32])=[CH:30][C:29]2[C:24](=[CH:25][CH:26]=[C:27]([O:33][CH3:34])[CH:28]=2)[N:23]=1>>[Cl:32][C:31]1[C:22]([C:9]2[CH2:14][CH2:13][CH:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:11][CH:10]=2)=[N:23][C:24]2[C:29]([CH:30]=1)=[CH:28][C:27]([O:33][CH3:34])=[CH:26][CH:25]=2

Participants

3

Reactant 2

HCID 397332932,3-Dichloro-6-methoxyquinoline2×HCID 592787964-(4,4,5,5-Tetramethyl-(1,3,2)dioxaborolan-2-yl)cyclohex-3-ene-1-carboxylic acid ethyl ester

Product 1

HCID 66980116Ethyl 4-(3-chloro-6-methoxyquinolin-2-yl)cyclohex-3-enecarboxylate

Procedure

Followed Scheme 2, Step 1 (see Example 8, Step 1) starting from ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-enecarboxylate and 2,3-dichloro-6-methoxyquinoline (Intermediate 4).

Sources & evidence

ORD record
ord-a5e9ec7846a04baa97d7748d3f572939
Source dataset
uspto-grants-2015_12
Patent number
US09221810B2

Reaction notes

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