Hydrochloric Acid → HCID 117701575, compound

HRID 1507458Notes

Reaction equation

HRID 1507458 reaction equation
[ClH:1].[C:2]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[O:12][C:13]3[C:18]([C:19](=[O:22])[C:20]=2[CH3:21])=[CH:17][CH:16]=[C:15]([O:23]COC)[C:14]=3[CH3:27])[CH2:7][CH2:6]1)(=[O:4])[CH3:3]>O1CCOCC1>[ClH:1].[C:2]([N:5]1[CH2:6][CH2:7][N:8]([C:11]2[O:12][C:13]3[C:18]([C:19](=[O:22])[C:20]=2[CH3:21])=[CH:17][CH:16]=[C:15]([OH:23])[C:14]=3[CH3:27])[CH2:9][CH2:10]1)(=[O:4])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117701583HCID 117701583, compound

Product 1

HCID 117701575HCID 117701575, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A 4 N solution of hydrochloric acid in dioxane (1 mL) was added to a solution of 2-(4-acetylpiperazin-1-yl)-7-(methoxymethoxy)-3,8-dimethyl-4H-chromen-4-one (60 mg, 0.17 mmol) obtained in Example 37-4 in dioxane (3 mL), and the mixture was stirred at room temperature for 15 minutes. The deposited crystals were washed with dioxane and isopropyl ether and then collected by filtration to obtain 36 mg of the title compound (yield: 63%).

Workup

  1. washThe deposited crystals were washed with dioxane and isopropyl ether
  2. filtrationcollected by filtration

Sources & evidence

ORD record
ord-0cd1b5e203a6437985e27b6364492e47
Source dataset
uspto-grants-2015_12
Patent number
US09221811B2

Reaction notes

Loading…