Acetone → HCID 131734373, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred suspension of 5 g Vemurafenib base and 50 ml acetone (T=30-35° C.), 3.0 ml choline (45% in methanol) was added. The obtained solution was stirred for 5 min at 35° C. and then cooled to RT. After evaporation of the solvent, a solid was obtained. 15 ml isopropanol was added, the suspension was placed in an ultrasonic bath (suspension, no solution was formed) and then stored in the refrigerator for 1 days. The precipitate was filtered off, washed with 5 ml isopropanol and dried at RT O/N. 2.07 g (yield: 80.5%).

Provenance & Evidence