反应详情

温度

35 °C

To a stirred suspension of 5 g Vemurafenib base and 50 ml acetone (T=30-35° C.), 3.0 ml choline (45% in methanol) was added. The obtained solution was stirred for 5 min at 35° C. and then cooled to RT. After evaporation of the solvent, a solid was obtained. 15 ml isopropanol was added, the suspension was placed in an ultrasonic bath (suspension, no solution was formed) and then stored in the refrigerator for 1 days. The precipitate was filtered off, washed with 5 ml isopropanol and dried at RT O/N. 2.07 g (yield: 80.5%).

1. additionwas added
2. temperaturecooled to RT
3. customAfter evaporation of the solvent
4. customa solid was obtained
5. customthe suspension was placed in an ultrasonic bath
6. custom(suspension, no solution was formed) and
7. waitthen stored in the refrigerator for 1 days
8. filtrationThe precipitate was filtered off
9. washwashed with 5 ml isopropanol
10. customdried at RT O/N